In humans, bilateral hippocampal atrophy can lead to profound impairments in episodic memory. Across species, perhaps the most well established contribution of the hippocampus to memory is not to episodic memory generally but to allocentric spatial memory. However, the extent to which navigational spatial memory depends on hippocampal integrity in humans is not well documented. We investigated spatial recall using a virtual environment in two groups of patients with hippocampal damage (moderate/severe) and a normal control group.
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The 2014 Nobel prize in Medicine was awarded for the discovery of the brain’s GPS in the rodent entorhinal cortex. Despite numerous attempts in neuroscience and medicine in the past decades, the homologue entorhinal subregions in humans remained elusive. In this study, we combine high-field fMRI with novel connectivity methods to identify the corresponding areas in humans.
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We’ve all had that ‘Aha!’ moment when pieces of a puzzling problem seem to fall into place as we gain insight into a previously obscured solution. But what happens in our brains when we think ‘Aha!’? That was the question that Branka Milivojevic, Alejandro Vicente-Grabovetsky and Christian Doeller sought to answer.
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When we remember an event, it is as if we travel back in time to the original experience of that event. In this study, we asked whether this reinstatement also happens for simple audio-visual associations.
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