All Posts By

Jacob Bellmund

Visual Grids in MEG

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Our new study is out in Current Biology. Staudigl et al. show grid-like modulation of human high frequency activity in non-invasive magnetoencephalographic and intracranial EEG recordings. The results indicate that the human entorhinal cortex codes visual space in a grid-like manner, supporting the view that grid-coding generalizes beyond environmental mapping during locomotion.

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Silvy Collin awarded NWO Rubicon

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Silvy Collin has been awarded the Rubicon grant by The Netherlands Organisation for Scientific Research (NWO) to continue her scientific career at the Princeton Computational Neuroscience lab lead by Ken Norman. During her postdoc there she wants to investigate how the brain structures continuous, real-life experience with the use of computational modeling, neuroimaging and realistic episodic memory tasks. We wish Silvy all the best for her future!

Read more on the NWO website.

New paper shows grid-like entorhinal signals in imagination

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How do we plan our way from A to B? Imagine you are planning your way home from your favorite café. You need to know both the location of the café and your home as well as the direction between them to find the best route. Imagining what you will see when exiting the café allows you to determine whether to turn left or right. Our new paper, published in eLife, shows that representations of facing direction and grid-cell computations play a role in mental simulation in service of navigational planning.

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New Paper in Neurobiology of Aging on Dopamine modulation of spatial memory in Parkinson’s Disease

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A key feature of Parkinson’s disease (PD) is the depletion of striatal dopamine, which is associated with the motor and non-motor symptoms of the disease. In this study, we sought to investigate the role of dopamine in spatial memory in PD patients in a cross-over medication ON/OFF design. We used a virtual reality task to assess striatal- and hippocampal-dependent spatial memory. Results show that PD patients and age-matched controls rely more on striatal cue-based spatial learning than the young adults tested in previous studies. Medication improved striatal-dependent spatial memory. The benefit of medication on hippocampal-dependent spatial memory depended on prior experience with the task. These findings shed new light on dopaminergic modulation of hippocampal-striatal functions in PD.

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